Sign in

Nuclear Receptor Inhibitors

Modulate physiological processes, including metabolism, immune modulation, and hormonal signaling with our range of nuclear receptors inhibitors.

Browse Nuclear Receptor inhibitors

Browse Nuclear Receptors

Nuclear receptors are ligand-activated transcription factors that regulate gene expression in response to hormonal and metabolic cues. Their dysregulation is associated with diseases such as hormone-dependent cancers, cardiovascular disorders, and metabolic syndromes. For instance, overactive androgen receptors (AR) fuel prostate cancer progression, while impaired peroxisome proliferator-activated receptor gamma (PPARγ) function contributes to insulin resistance and type 2 diabetes. Consequently, these receptors key drug targets, and their inhibition allows transcriptional modulation.

Read more

Home > Products > Biochemicals > Small Molecule Inhibitors > Nuclear Receptors

2-Chloro-5-nitro-N-phenylbenzamide

2-Chloro-5-nitro-N-phenylbenzamide

{"author_name":"[email protected]","post_title":"2-Chloro-5-nitro-N-phenylbenzamide","has_stock":{"has_stock_uk":"false","has_stock_germany":"false","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F497827_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F497827_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F497827_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F497827_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F497827_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F497827_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F497827_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F497827_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F497827_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F497827_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F497827_sv.pdf"},"min_max_price":{"min_gbp_base_price":102,"max_gbp_base_price":349},"transport":[],"post_content":"CAS [22978-25-2]","hazards":{"signal_word":"Warning","hazard_statements":["H302 - Harmful if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F497827.json","post_name":"2-chloro-5-nitro-n-phenylbenzamide","post_date":"2025-03-21T15:02:56+00:00","meta":{"_cas":"22978-25-2","_canonicalsmiles":"O=C(Nc1ccccc1)c1cc([N+](=O)[O-])ccc1Cl","_inchi":"InChI=1S\/C13H9ClN2O3\/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9\/h1-8H,(H,15,17)","_inchikey":"DNTSIBUQMRRYIU-UHFFFAOYSA-N","_mdl":"MFCD01215270","_molecularformula":"C13H9ClN2O3","_unspsc":12352100,"_sku":"F497827","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:16:42","ID":"920435","post_status":"publish","categories":{"concept_groups":["Phenyl","Amide","Nitro","Chlorinated","Halogenated","Disubstituted (2,4)- monochlorobenzene","Monochlorobenzene","Nitrobenzene","Cyclic","Aromatic","Benzanilide","1-Chloro-4-nitrobenzene","1-Halo-4-nitrobenzene"],"term_id":[58]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F497827\/","properties":{"purity":"97.0%","molecular_weight":"276.68","state":"Liquid","appearance":"No data available."}}

5,5-Dimethyl-2-thioxoimidazolidin-4-one

5,5-Dimethyl-2-thioxoimidazolidin-4-one

{"author_name":"[email protected]","post_title":"5,5-Dimethyl-2-thioxoimidazolidin-4-one","has_stock":{"has_stock_uk":"false","has_stock_germany":"true","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F615002_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F615002_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F615002_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F615002_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F615002_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F615002_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F615002_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F615002_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F615002_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F615002_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F615002_sv.pdf"},"min_max_price":{"min_gbp_base_price":28,"max_gbp_base_price":234},"transport":{"shipping_name":"Non Hazardous For Transport"},"post_content":"CAS [15998-93-3]","hazards":{"signal_word":"Warning","hazard_statements":["H302 - Harmful if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F615002.json","post_name":"55-dimethyl-2-thioxoimidazolidin-4-one","post_date":"2025-03-21T17:53:38+00:00","meta":{"_cas":"15998-93-3","_iupac":"5,5-dimethyl-2-sulfanylideneimidazolidin-4-one","_canonicalsmiles":"CC1(C)NC(=S)NC1=O","_inchi":"InChI=1S\/C5H8N2OS\/c1-5(2)3(8)6-4(9)7-5\/h1-2H3,(H2,6,7,8,9)","_inchikey":"QSAASNVWPNBKDI-UHFFFAOYSA-N","_mdl":"MFCD24549235","_unspsc":12352100,"_sku":"F615002","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:17:03","ID":"971927","post_status":"publish","categories":{"concept_groups":["Heterocycle","Amide","Methyl","Dimethyl","Lactam","5-Membered heterocycle","Imidazolidine","Cyclic"],"term_id":[58]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F615002\/","properties":{"purity":"97%","molecular_weight":"144.1900024","asymmetric_atoms":0,"logp":0.441179245,"h_bond_acceptors":1,"h_bond_donors":2,"fsp3":0.6,"state":"Solid"}}

4-(3-(4-CYANO-3-(TRIFLUOROMETHYL)PHENYL)-5,5-DIMETHYL-4-OXO-2-THIOXOIMIDAZOLIDIN-1-YL)-2-FLUOROBENZOIC ACID

4-(3-(4-CYANO-3-(TRIFLUOROMETHYL)PHENYL)-5,5-DIMETHYL-4-OXO-2-THIOXOIMIDAZOLIDIN-1-YL)-2-FLUOROBENZOIC ACID

{"author_name":"[email protected]","post_title":"4-(3-(4-CYANO-3-(TRIFLUOROMETHYL)PHENYL)-5,5-DIMETHYL-4-OXO-2-THIOXOIMIDAZOLIDIN-1-YL)-2-FLUOROBENZOIC ACID","has_stock":{"has_stock_uk":"false","has_stock_germany":"false","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F843830_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F843830_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F843830_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F843830_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F843830_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F843830_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F843830_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F843830_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F843830_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F843830_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F843830_sv.pdf"},"min_max_price":{"min_gbp_base_price":79,"max_gbp_base_price":2920},"transport":{"shipping_name":"Non Hazardous For Transport"},"post_content":"CAS [1242137-15-0]","hazards":{"signal_word":"Warning","hazard_statements":["H302 - Harmful if swallowed."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P261 - Avoid breathing dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P308+P313 - IF exposed or concerned: Get medical advice\/attention.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F843830.json","post_name":"4-3-4-cyano-3-trifluoromethylphenyl-55-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl-2-fluorobenzoic-acid","post_date":"2025-03-22T15:04:34+00:00","meta":{"_cas":"1242137-15-0","_iupac":"4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-2-fluorobenzoic acid","_canonicalsmiles":"CC1(C)N(C(=S)N(C1=O)C1=CC=C(C#N)C(=C1)C(F)(F)F)C1=CC=C(C(O)=O)C(F)=C1","_inchi":"InChI=1S\/C20H13F4N3O3S\/c1-19(2)17(30)26(11-4-3-10(9-25)14(7-11)20(22,23)24)18(31)27(19)12-5-6-13(16(28)29)15(21)8-12\/h3-8H,1-2H3,(H,28,29)","_inchikey":"MECDPCCFIDQBBP-UHFFFAOYSA-N","_mdl":"MFCD28411442","_unspsc":12352100,"_sku":"F843830","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:18:07","ID":"1186054","post_status":"publish","categories":{"concept_groups":["Phenyl","Carboxylic acid","Heterocycle","Amide","Nitrile","Fluorinated","Halogenated","Methyl","Dimethyl","Trifluoromethyl","Lactam","5-Membered heterocycle","Disubstituted (2,5)- monofluorobenzene","Imidazolidine","Monofluorobenzene","Cyclic","Aromatic","Benzoic acid","Benzonitrile"],"term_id":[58]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F843830\/","properties":{"purity":"95%","molecular_weight":"451.3999939","asymmetric_atoms":0,"logp":4.738677788,"h_bond_acceptors":4,"h_bond_donors":1,"fsp3":0.2}}

APALUTAMIDE

{"author_name":"[email protected]","post_title":"APALUTAMIDE","has_stock":{"has_stock_uk":"false","has_stock_germany":"false","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F857109_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F857109_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F857109_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F857109_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F857109_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F857109_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F857109_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F857109_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F857109_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F857109_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F857109_sv.pdf"},"min_max_price":{"min_gbp_base_price":72,"max_gbp_base_price":1115},"transport":{"shipping_name":"Non Hazardous For Transport"},"post_content":"CAS [956104-40-8]","hazards":{"signal_word":"Danger","hazard_statements":["H302 - Harmful if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation.","H360 - May damage fertility or the unborn child.","H373 - May cause damage to organs through prolonged or repeated exposure."],"precautionary_phrases":["P201 - Obtain special instructions before use.","P202 - Do not handle until all safety precautions have been read and understood.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P302+P352 - IF ON SKIN: Wash with plenty of water and soap.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P308+P313 - IF exposed or concerned: Get medical advice\/attention.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07","GHS08"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F857109.json","post_name":"apalutamide","post_date":"2025-03-22T16:51:51+00:00","meta":{"_cas":"956104-40-8","_iupac":"4-{7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl}-2-fluoro-N-methylbenzamide","_canonicalsmiles":"CNC(=O)C1=C(F)C=C(C=C1)N1C(=S)N(C(=O)C11CCC1)C1=CN=C(C#N)C(=C1)C(F)(F)F","_inchi":"InChI=1S\/C21H15F4N5O2S\/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12\/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)","_inchikey":"HJBWBFZLDZWPHF-UHFFFAOYSA-N","_mdl":"MFCD22380626","_einecs":"807-449-9","_unspsc":12352100,"_sku":"F857109","_synonyms":["4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide"]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:18:08","ID":"1198626","post_status":"publish","categories":{"concept_groups":["Phenyl","Heterocycle","Heteroaromatic","Amide","Nitrile","Fluorinated","Halogenated","N-methyl","Trifluoromethyl","Lactam","5-Membered heterocycle","6-Membered heteroaromatic","6-Membered heterocycle","Disubstituted (2,5)- monofluorobenzene","Monofluorobenzene","Pyridine","Spirocycle","Cyclic","Aromatic"],"term_id":[58]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F857109\/","properties":{"purity":"95%","molecular_weight":"477.4400024","asymmetric_atoms":0,"logp":3.460339361,"h_bond_acceptors":4,"h_bond_donors":1,"fsp3":0.285714285714286,"state":"Solid","relative_density":"1.59"}}

4-(3-(4-HYDROXYPHENYL)-4,4-DIMETHYL-5-OXO-2-THIOXOIMIDAZOLIDIN-1-YL)-2-(TRIFLUOROMETHYL)BENZONITRILE

4-(3-(4-HYDROXYPHENYL)-4,4-DIMETHYL-5-OXO-2-THIOXOIMIDAZOLIDIN-1-YL)-2-(TRIFLUOROMETHYL)BENZONITRILE

{"author_name":"[email protected]","post_title":"4-(3-(4-HYDROXYPHENYL)-4,4-DIMETHYL-5-OXO-2-THIOXOIMIDAZOLIDIN-1-YL)-2-(TRIFLUOROMETHYL)BENZONITRILE","has_stock":{"has_stock_uk":"false","has_stock_germany":"false","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F859812_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F859812_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F859812_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F859812_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F859812_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F859812_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F859812_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F859812_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F859812_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F859812_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F859812_sv.pdf"},"min_max_price":{"min_gbp_base_price":12,"max_gbp_base_price":135},"transport":{"shipping_name":"Non Hazardous For Transport"},"post_content":"CAS [915086-32-7]","hazards":{"signal_word":"Warning","hazard_statements":["H302 - Harmful if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F859812.json","post_name":"4-3-4-hydroxyphenyl-44-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl-2-trifluoromethylbenzonitrile","post_date":"2025-03-22T17:03:01+00:00","meta":{"_cas":"915086-32-7","_iupac":"4-[3-(4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile","_canonicalsmiles":"CC1(C)N(C(=S)N(C1=O)C1=CC(=C(C=C1)C#N)C(F)(F)F)C1=CC=C(O)C=C1","_inchi":"InChI=1S\/C19H14F3N3O2S\/c1-18(2)16(27)24(17(28)25(18)12-5-7-14(26)8-6-12)13-4-3-11(10-23)15(9-13)19(20,21)22\/h3-9,26H,1-2H3","_inchikey":"VIMSHSUYAZHWKM-UHFFFAOYSA-N","_mdl":"MFCD28978634","_unspsc":12352100,"_sku":"F859812","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:18:08","ID":"1199926","post_status":"publish","categories":{"concept_groups":["Phenyl","Heterocycle","Amide","Nitrile","Fluorinated","Halogenated","Methyl","Dimethyl","Aromatic alcohol","Trifluoromethyl","Lactam","5-Membered heterocycle","Imidazolidine","Phenol","Cyclic","Aromatic","Benzonitrile"],"term_id":[58]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F859812\/","properties":{"purity":"95%","molecular_weight":"405.3999939","asymmetric_atoms":0,"logp":4.634827622,"h_bond_acceptors":3,"h_bond_donors":1,"fsp3":0.210526315789474}}

N-desmethyl Enzalutamide

N-desmethyl Enzalutamide

{"author_name":"[email protected]","post_title":"N-desmethyl Enzalutamide","has_stock":{"has_stock_uk":"false","has_stock_germany":"false","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F987630_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F987630_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F987630_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F987630_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F987630_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F987630_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F987630_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F987630_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F987630_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F987630_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F987630_sv.pdf"},"min_max_price":{"min_gbp_base_price":60,"max_gbp_base_price":994},"transport":{"shipping_name":"Non Hazardous For Transport"},"post_content":"CAS [1242137-16-1]","hazards":{"signal_word":"Warning","hazard_statements":["H302 - Harmful if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F987630.json","post_name":"n-desmethyl-enzalutamide","post_date":"2025-03-22T21:31:45+00:00","meta":{"_cas":"1242137-16-1","_iupac":"4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-2-fluorobenzamide","_canonicalsmiles":"CC1(C)N(C(=S)N(C1=O)C1=CC=C(C#N)C(=C1)C(F)(F)F)C1=CC(F)=C(C=C1)C(N)=O","_inchi":"InChI=1S\/C20H14F4N4O2S\/c1-19(2)17(30)27(11-4-3-10(9-25)14(7-11)20(22,23)24)18(31)28(19)12-5-6-13(16(26)29)15(21)8-12\/h3-8H,1-2H3,(H2,26,29)","_inchikey":"JSFOGZGIBIQRPU-UHFFFAOYSA-N","_unspsc":12352100,"_sku":"F987630","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:18:12","ID":"1230948","post_status":"publish","categories":{"concept_groups":["Phenyl","Heterocycle","Amide","Nitrile","Fluorinated","Halogenated","Methyl","Dimethyl","Trifluoromethyl","Lactam","5-Membered heterocycle","Disubstituted (2,5)- monofluorobenzene","Imidazolidine","Monofluorobenzene","Cyclic","Aromatic","Benzonitrile"],"term_id":[58]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F987630\/","properties":{"molecular_weight":"450.41","asymmetric_atoms":0,"logp":3.93173517433333,"h_bond_acceptors":3,"h_bond_donors":1,"fsp3":0.2}}

No results found. Please try adjusting your search criteria.

Nuclear receptor inhibitors act through diverse mechanisms such as blocking ligand binding, disrupting cofactor recruitment, or altering receptor conformation. Tamoxifen, a selective estrogen receptor modulator (SERM), competitively blocks estrogen binding, reducing proliferation in ER-positive breast cancer. Bexarotene, a retinoic acid receptor (RAR) agonist, is used in cutaneous T-cell lymphoma by promoting cell differentiation and apoptosis. Mifepristone, a glucocorticoid and progesterone receptor antagonist, is used to manage Cushing’s syndrome by disrupting hormone signaling.

Emerging therapies include Enzalutamide, an androgen receptor (AR) inhibitor that effectively blocks testosterone-driven prostate cancer progression, and T0901317, a liver X receptor (LXR) inhibitor that modulates cholesterol metabolism and inflammation. Advances in AI-assisted drug discovery and structure-based design continue to refine next-generation inhibitors, enhancing selectivity and minimizing off-target effects. These breakthroughs are expanding treatment options for oncology, metabolic diseases, and endocrine disorders.