Sign in

Proteases

Browse Proteases

Browse Proteases

Small molecule activators of proteases enhance the catalytic activity of these enzymes. Proteases are essential for protein turnover, immune defense, and cell signaling. They have diverse roles in apoptosis, inflammation, and extracellular matrix remodeling.

Read more

Home > Products > Biochemicals > Small Molecule Activators > Proteases

4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline

4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline

{"author_name":"[email protected]","post_title":"4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline","has_stock":{"has_stock_uk":"true","has_stock_germany":"false","has_stock_china":"false","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F386709_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F386709_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F386709_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F386709_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F386709_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F386709_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F386709_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F386709_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F386709_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F386709_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F386709_sv.pdf"},"min_max_price":{"min_gbp_base_price":14,"max_gbp_base_price":261},"transport":{"un_number":2811,"packing_group":"III","hazard_class":6.1,"hazard_subclass":"","shipping_name":"TOXIC SOLID, ORGANIC, N.O.S."},"post_content":"CAS [99011-02-6]","hazards":{"signal_word":"Danger","hazard_statements":["H301 - Toxic if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P202 - Do not handle until all safety precautions have been read and understood.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P302+P352 - IF ON SKIN: Wash with plenty of water and soap.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P308+P313 - IF exposed or concerned: Get medical advice\/attention.","P310 - Immediately call a POISON CENTER\/doctor.","P321 - Specific treatment (see Section 4 on this SDS).","P342+P311 - If experiencing respiratory symptoms: Call a POISON CENTER\/doctor.","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS06","GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F386709.json","post_name":"4-amino-1-isobutyl-1h-imidazo45-cquinoline","post_date":"2025-03-21T13:47:38+00:00","meta":{"_cas":"99011-02-6","_canonicalsmiles":"CC(C)Cn1cnc2c(N)nc3ccccc3c21","_inchi":"InChI=1S\/C14H16N4\/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15\/h3-6,8-9H,7H2,1-2H3,(H2,15,17)","_inchikey":"DOUYETYNHWVLEO-UHFFFAOYSA-N","_mdl":"MFCD00866946","_molecularformula":"C14H16N4","_unspsc":12352100,"_sku":"F386709","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:16:29","ID":"890550","post_status":"publish","categories":{"concept_groups":["Heterocycle","Heteroaromatic","Primary amine","Amine (P+S+T)","5-Membered heteroaromatic","5-Membered heterocycle","6-Membered heteroaromatic","6-Membered heterocycle","Cyclic","Aromatic"],"term_id":[64,81]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F386709\/","properties":{"purity":"97.0%","molecular_weight":"240.31","state":"Solid","partition_coefficient":"2.91","appearance":"Solid"}}

Tosyl-L-Phenylalanine chloromethylketone

Tosyl-L-Phenylalanine chloromethylketone

{"post_title":"Tosyl-L-Phenylalanine chloromethylketone","sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F493163_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F493163_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F493163_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F493163_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F493163_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F493163_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F493163_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F493163_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F493163_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F493163_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F493163_sv.pdf"},"transport":[],"post_content":"CAS [402-71-1]","hazards":{"signal_word":"Danger","hazard_statements":["H315 - Causes skin irritation.","H318 - Causes serious eye damage.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P261 - Avoid breathing dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P312.1 - IF SWALLOWED: Call a doctor if you feel unwell.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P308+P313 - IF exposed or concerned: Get medical advice\/attention.","P312 - Call a POISON CENTER\/doctor if you feel unwell.","P321 - Specific treatment (see Section 4 on this SDS).","P337+P313 - If eye irritation persists: Get medical advice\/attention.","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS05","GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F493163.json","post_name":"tosyl-l-phenylalanine-chloromethylketone","post_date":"2025-06-03T20:10:46+00:00","meta":{"_cas":"402-71-1","_canonicalsmiles":"Cc1ccc(S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)CCl)cc1","_inchi":"InChI=1S\/C17H18ClNO3S\/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14\/h2-10,16,19H,11-12H2,1H3\/t16-\/m0\/s1","_inchikey":"MQUQNUAYKLCRME-INIZCTEOSA-N","_mdl":"MFCD00000935","_molecularformula":"C17H18ClNO3S","_unspsc":12352100,"_sku":"F493163","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:16:40","ID":"2145235","post_status":"publish","categories":{"concept_groups":["Phenyl","Ketone","Chlorinated","Halogenated","Chiral","Sulfonamide","Methyl","Tolyl","Cyclic","Aromatic"],"term_id":[64]},"permalink":"https:\/\/fluorochem.build\/product\/F493163\/","properties":{"purity":"95.0%","molecular_weight":"351.85","state":"Solid","melting_point":"108\u00b0C","appearance":"Solid"}}

No results found. Please try adjusting your search criteria.

Protease activation mechanisms vary depending on enzyme class. Some activators interact with allosteric domains, shifting the protease into an optimal catalytic state, while others act on zymogens, inactive precursors, facilitating their conversion into active enzymes. Serine, cysteine, aspartic, and metalloproteases all rely on these regulatory pathways to control biological functions such as digestion, wound healing, and neuroprotection.

Therapeutically, protease activators are being explored for their role in neurodegeneration, blood coagulation, and immune modulation. Plasminogen activators, like tPA, improve stroke recovery by breaking down blood clots, while ADAMTS metalloprotease activators promote cartilage repair in osteoarthritis. Modulating protease activity offers targeted approaches to disease treatment and tissue regeneration.

Advancements in structural biology, high-throughput screening, and computational modelling are refining the discovery of selective protease activators. By targeting specific enzyme conformations and regulatory pathways, researchers are optimising these compounds for enhanced efficacy and reduced off-target interactions, expanding their potential in both fundamental science and medical applications.