PROTACs

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{"author_name":"[email protected]","post_title":"GMB-475","has_stock":{"has_stock_uk":"false","has_stock_germany":"false","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F840929_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F840929_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F840929_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F840929_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F840929_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F840929_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F840929_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F840929_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F840929_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F840929_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F840929_sv.pdf"},"min_max_price":{"min_gbp_base_price":263,"max_gbp_base_price":1440},"transport":{"shipping_name":"Non Hazardous For Transport"},"post_content":"CAS [2490599-18-1]","hazards":{"signal_word":"Warning","hazard_statements":["H302 - Harmful if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F840929.json","post_name":"gmb-475","post_date":"2025-03-22T14:42:39+00:00","meta":{"_cas":"2490599-18-1","_iupac":"(2S,4R)-1-[(2S)-3,3-dimethyl-2-(2-{2-[4-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)phenoxy]ethoxy}acetamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide","_canonicalsmiles":"CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOC2=CC=C(C=C2)C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)C(C)(C)C)C=C1","_inchi":"InChI=1S\/C43H46F3N7O7S\/c1-26-38(61-25-50-26)29-7-5-27(6-8-29)21-47-40(56)35-19-31(54)22-53(35)41(57)39(42(2,3)4)52-37(55)23-58-17-18-59-32-13-9-28(10-14-32)34-20-36(49-24-48-34)51-30-11-15-33(16-12-30)60-43(44,45)46\/h5-16,20,24-25,31,35,39,54H,17-19,21-23H2,1-4H3,(H,47,56)(H,52,55)(H,48,49,51)\/t31-,35+,39-\/m1\/s1","_inchikey":"ONDVWISBMHHLGZ-SBJIGXGQSA-N","_mdl":"MFCD32220458","_unspsc":12352100,"_sku":"F840929","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:18:07","ID":"1183494","post_status":"publish","categories":{"concept_groups":["Phenyl","Aliphatic alcohol","Ether","Heterocycle","Heteroaromatic","Amide","Secondary amine","Amine (P+S+T)","Sulfide","Fluorinated","Halogenated","Chiral","Methyl","Trifluoromethyl","Trifluoromethoxy","5-Membered heteroaromatic","5-Membered heterocycle","6-Membered heteroaromatic","6-Membered heterocycle","Chiral alcohol","Chiral amide","Chiral amino alcohol (all)","Chiral amino alcohol (chiral alcohol)","Pyrimidine","Pyrrolidine","Thiazole","Trifluoromethoxy benzene","Cyclic","Aromatic","PROTAC: Ligand | VHL Building Block 1(Thiazole Chain)"],"term_id":[69]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F840929\/","properties":{"purity":"95%","molecular_weight":"861.9400024","asymmetric_atoms":3,"logp":5.71436957833333,"h_bond_acceptors":11,"h_bond_donors":4,"fsp3":0.348837209302326}}

{"author_name":"[email protected]","post_title":"Gefitinib-based PROTAC 3","has_stock":{"has_stock_uk":"false","has_stock_germany":"false","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F986380_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F986380_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F986380_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F986380_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F986380_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F986380_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F986380_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F986380_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F986380_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F986380_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F986380_sv.pdf"},"min_max_price":{"min_gbp_base_price":136,"max_gbp_base_price":227},"transport":{"shipping_name":"Non Hazardous For Transport"},"post_content":"CAS [2230821-27-7]","hazards":{"signal_word":"Warning","hazard_statements":["H302 - Harmful if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F986380.json","post_name":"gefitinib-based-protac-3","post_date":"2025-03-22T21:23:37+00:00","meta":{"_cas":"2230821-27-7","_iupac":"(2S,4R)-1-[(2S)-2-[3-(2-{[5-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)pentyl]oxy}ethoxy)propanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide","_canonicalsmiles":"COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1)C1=C(C)N=CS1)C(C)(C)C","_inchi":"InChI=1S\/C47H57ClFN7O8S\/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64-40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32\/h9-14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)\/t33-,38+,43-\/m1\/s1","_inchikey":"NICKHWYZMNLEPJ-TZSMONEZSA-N","_unspsc":12352100,"_sku":"F986380","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:18:11","ID":"1230114","post_status":"publish","categories":{"concept_groups":["Phenyl","Aliphatic alcohol","Methoxy","Ether","Heterocycle","Heteroaromatic","Amide","Secondary amine","Amine (P+S+T)","Sulfide","Fluorinated","Chlorinated","Halogenated","Chiral","Methyl","5-Membered heteroaromatic","5-Membered heterocycle","6-Membered heteroaromatic","6-Membered heterocycle","Chiral alcohol","Chiral amide","Chiral amino alcohol (all)","Chiral amino alcohol (chiral alcohol)","Disubstituted (2,4)- monofluorobenzene","Disubstituted (2,5)- monochlorobenzene","Monochlorobenzene","Monofluorobenzene","Pyrrolidine","Quinazoline","Thiazole","Cyclic","Aromatic","PROTAC: Ligand | VHL Building Block 1(Thiazole Chain)"],"term_id":[69]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F986380\/","properties":{"molecular_weight":"934.52","asymmetric_atoms":3,"logp":5.42651303666666,"h_bond_acceptors":12,"h_bond_donors":4,"fsp3":0.446808510638298}}

{"author_name":"[email protected]","post_title":"ARV-825","has_stock":{"has_stock_uk":"false","has_stock_germany":"false","has_stock_china":"true","has_stock_any":"true"},"sds_links":{"EN":"https:\/\/sds.fluorochem.co.uk\/eng\/sds_F986640_en.pdf","DA":"https:\/\/sds.fluorochem.co.uk\/dan\/sds_F986640_da.pdf","NL":"https:\/\/sds.fluorochem.co.uk\/nld\/sds_F986640_nl.pdf","FI":"https:\/\/sds.fluorochem.co.uk\/fin\/sds_F986640_fi.pdf","FR":"https:\/\/sds.fluorochem.co.uk\/fra\/sds_F986640_fr.pdf","DE":"https:\/\/sds.fluorochem.co.uk\/deu\/sds_F986640_de.pdf","IT":"https:\/\/sds.fluorochem.co.uk\/ita\/sds_F986640_it.pdf","NO":"https:\/\/sds.fluorochem.co.uk\/nor\/sds_F986640_no.pdf","PT":"https:\/\/sds.fluorochem.co.uk\/por\/sds_F986640_pt.pdf","ES":"https:\/\/sds.fluorochem.co.uk\/spa\/sds_F986640_es.pdf","SV":"https:\/\/sds.fluorochem.co.uk\/swe\/sds_F986640_sv.pdf"},"min_max_price":{"min_gbp_base_price":156,"max_gbp_base_price":807},"transport":{"shipping_name":"Non Hazardous For Transport"},"post_content":"CAS [1818885-28-7]","hazards":{"signal_word":"Warning","hazard_statements":["H302 - Harmful if swallowed.","H315 - Causes skin irritation.","H319 - Causes serious eye irritation.","H335 - May cause respiratory irritation."],"precautionary_phrases":["P101 - If medical advice is needed, have product container or label at hand.","P260 - Do not breathe dust\/fume\/gas\/mist\/vapours\/spray.","P264 - Wash hands thoroughly after handling.","P270 - Do not eat, drink or smoke when using this product.","P271 - Use only outdoors or in a well-ventilated area.","P280 - Wear protective gloves\/protective clothing and eye\/face protection.","P301+P310 - IF SWALLOWED: Immediately call a POISON CENTER\/doctor.","P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.","P303+P361+P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.","P304+P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing.","P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.","P321 - Specific treatment (see Section 4 on this SDS).","P362+P364 - Take off contaminated clothing and wash it before reuse.","P403+P233 - Store in a well-ventilated place. Keep container tightly closed.","P405 - Store locked up.","P501 - Dispose of contents\/container to hazardous waste disposal."],"ghs_pictograms":["GHS07"]},"variants_blob_url":"https:\/\/fluorochemcouk.blob.core.windows.net\/pricing\/F986640.json","post_name":"arv-825","post_date":"2025-03-22T21:28:39+00:00","meta":{"_cas":"1818885-28-7","_iupac":"2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0\u00b2,\u2076]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[4-(2-{2-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethoxy}ethoxy)phenyl]acetamide","_canonicalsmiles":"CC1=NN=C2[C@H](CC(=O)NC3=CC=C(OCCOCCOCCOCCNC4=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=CC=C4)C=C3)N=C(C3=C(SC(C)=C3C)N12)C1=CC=C(Cl)C=C1","_inchi":"InChI=1S\/C46H47ClN8O9S\/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58\/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)\/t35-,36?\/m0\/s1","_inchikey":"RWLOGRLTDKDANT-TYIYNAFKSA-N","_unspsc":12352100,"_sku":"F986640","_synonyms":[]},"shipping_times":{"UK":"UK Stock, Next Day, Germany Stock 3- 5 days, China Stock 10 - 14 days.","EU":"EU Stock, Next Day, UK Stock 3- 5 days, China Stock 10 - 14 days."},"post_type":"product","post_modified":"2025-06-27T17:18:11","ID":"1230630","post_status":"publish","categories":{"concept_groups":["Phenyl","Ether","Heterocycle","Heteroaromatic","Amide","Secondary amine","Amine (P+S+T)","Imide","Sulfide","Chlorinated","Halogenated","Chiral","Methyl","Lactam","5-Membered heteroaromatic","5-Membered heterocycle","6-Membered heterocycle","7-Membered heterocycle","Monochlorobenzene","Monosubstituted (para) monochlorobenzene","Piperidine","Cyclic","Aromatic","PEG-4","Isoindoline","Phthalimide"],"term_id":[69]},"author_id":"1946","permalink":"https:\/\/fluorochem.build\/product\/F986640\/","properties":{"molecular_weight":"923.44","asymmetric_atoms":2,"logp":5.15848952633334,"h_bond_acceptors":13,"h_bond_donors":3,"fsp3":0.347826086956522}}

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